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Recerca

A l'avantguarda de la biomedicina

Publicacions de recerca

Grups de recerca (Tots)
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis
Sabaté-Pérez, A; Romero, M; Sànchez-Fernàndez-de-Landa, P; Carobbio, S; Mouratidis, M; Sala, D; Engel, P; Villena, JA; Virtue, S; Vidal-Puig, A; Palacín, M; Testar, X; Zorzano, A
Autophagy
19
3
904 -
925
2023
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Wculek SK#, Heras-Murillo I, Mastrangelo A, Mañanes D, Galán M, Miguel V, Curtabbi A, Barbas, C, Chandel NS, Enríquez JA, Lamas S, Sancho D#
(#) Corresponding author
Immunity
(56:1-15)
2023
Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans.
Carreté L; Ksiezopolska E; Pegueroles C; Gómez-Molero E; Saus E; Iraola-Guzmán S; Loska D; Bader O; Fairhead C; Gabaldón T
Current Biology
32
14
3219 -
3219
2022
Molecular glue degraders: From serendipity to hunting and design
Nieto-Barrado L; Domostegui A; Mayor-Ruiz C
In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.
-
-
177 -
204
2022
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
Aranda, J; Wieczor, M; Terrazas, M; Brun-Heath, I; Orozco, M
Chem Catalysis
2
5
1084 -
1099
2022
Implementing re-configurable biological computation with distributed multicellular consortia
Canadell, D; Ortiz-Vaquerizas, N; Mogas-Diez, S; de Nadal, E; Macia, J; Posas, F
Nucleic Acids Research
50
21
12578 -
12595
2022
Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
Pluta, R; Aragon, E; Prescott, NA; Ruiz, L; Mees, RA; Baginski, B; Flood, JR; Martin-Malpartida, P; Massague, J; David, Y; Macias, MJ
Nature Communications
13
1
7279 -
-
2022
A glutamine-based single α-helix scaffold to target globular proteins
Escobedo, A; Piccirillo, J; Aranda, J; Diercks, T; Mateos, B; Garcia-Cabau, C; Sánchez-Navarro, M; Topal, B; Biesaga, M; Staby, L; Kragelund, BB; García, J; Millet, O; Orozco, M; Coles, M; Crehuet, R; Salvatella, X
Nature Communications
13
1
7073 -
-
2022
Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis
Molnar, C; Reina, J; Herrero, A; Heinen, JP; Méndiz, V; Bonnal, S; Irimia, M; Sánchez-Jiménez, M; Sánchez-Molina, S; Mora, J; Gonzalez, C
Pnas Nexus
1
4
pgac222 -
-
2022
Illuminati: a form of gene expression plasticity in Drosophila neural stem cells
Goupil, A; Heinen, JP; Salame, R; Rossi, F; Reina, J; Pennetier, C; Simon, A; Skorski, P; Louzao, A; Bardin, AJ; Basto, R; Gonzalez, C
Development
149
22
200808 -
-
2022
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...
Nature
611
7936
603 -
613
2022
Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states
Zhu, JQ; Salvatella, X; Robustelli, P
Nature Communications
13
1
6390 -
-
2022
Deciphering the roadmap of in vivo reprogramming toward pluripotency
Chondronasiou, D; de Villarreal, JM; Melendez, E; Lynch, CJ; del Pozo, N; Kovatcheva, M; Aguilera, M; Prats, N; Real, FX; Serrano, M
Stem Cell Reports
17
11
2501 -
2517
2022
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation
Gonzalez-Arzola, K; Diaz-Quintana, A; Bernardo-Garcia, N; Martinez-Fabregas, J; Rivero-Rodriguez, F; Casado-Combreras, MA; Elena-Real, CA; Velazquez-Cruz, A; Gil-Caballero, S; Velazquez-Campoy, A; Szulc, E; Gavilan, MP; Ayala, I; Arranz, R; Rios, RM; Salvatella, X; Valpuesta, JM; Hermoso, JA; De la Rosa, MA; Diaz-Moreno, I
Nature Structural & Molecular Biology
29
10
1024 -
+
2022
The role of lipids in cancer progression and metastasis
Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA
Cell Metabolism
34
11
1675 -
1699
2022
The role of lipids in cancer progression and metastasis
Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA
Cell Metabolism
34
11
1675 -
1699
2022
Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
Ulsamer, A; Martínez-Limón, A; Bader, S; Rodríguez-Acebes, S; Freire, R; Méndez, J; de Nadal, E; Posas, F
Cell Reports
40
12
111375 -
-
2022
Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque
Fernández-Torras, A; Duran-Frigola, M; Bertoni, M; Locatelli, M; Aloy, P
Nature Communications
13
1
5304 -
-
2022
Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation
Duran-Arqué, B; Cañete, M; Castellazzi, CL; Bartomeu, A; Ferrer-Caelles, A; Reina, O; Caballé, A; Gay, M; Arauz-Garofalo, G; Belloc, E; Mendez, R
Genome Biology
23
1
192 -
-
2022
Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors
Rivas, EI; Linares, J; Zwick, M; Gómez-Llonin, A; Guiu, M; Labernadie, A; Badia-Ramentol, J; Lladó, A; Bardia, L; Pérez-Núñez, I; Martínez-Ciarpaglini, C; Tarazona, N; Sallent-Aragay, A; Garrido, M; Celià-Terrassa, T; Burgués, O; Gomis, RR; Albanell, J; Calon, A
Nature Communications
13
1
5310 -
-
2022
The lysosomal proteome of senescent cells contributes to the senescence secretome
Rovira, M; Sereda, R; Pladevall-Morera, D; Ramponi, V; Marin, I; Maus, M; Madrigal-Matute, J; Díaz, A; García, F; Muñoz, J; Cuervo, AM; Serrano, M
Aging Cell
21
10
e13707 -
-
2022
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
Bernués, J; Izquierdo-Boulstridge, A; Reina, O; Castejón, L; Fernández-Castañer, E; Leal, N; Guerrero-Pepinosa, N; Bonet-Costa, C; Vujatovic, O; Climent-Cantó, P; Azorín, F
Nucleic Acids Research
50
16
9212 -
9225
2022
Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs
Climent-Cantó, P; Molnar, C; Santabárbara-Ruiz, P; Prieto, C; Abril, JF; Serras, F; Gonzalez, C
Cells
11
16
2542 -
-
2022
Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure
Riera-Escamilla, A; Vockel, M; Nagirnaja, L; Xavier, MJ; Carbonell, A; Moreno-Mendoza, D; Pybus, M; Farnetani, G; Rosta, V; Cioppi, F; Friedrich, C; Oud, MS; van der Heijden, GW; Soave, A; Diemer, T; Ars, E; Sánchez-Curbelo, J; Kliesch, S; O'Bryan, MK; Ruiz-Castañe, E; Azorín, F; Veltman, JA; Aston, KI; Conrad, DF; Tüttelmann, F; Krausz, C
American Journal Of Human Genetics
109
8
1458 -
1471
2022
DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
Barissi, S; Sala, A; Wieczór, M; Battistini, F; Orozco, M
Nucleic Acids Research
50
16
9105 -
9114
2022
Discovering the drivers of clonal hematopoiesis
Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Communications
13
1
4267 -
-
2022
A single WNT enhancer drives specification and regeneration of the Drosophila wing
Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M
Nature Communications
13
1
4794 -
-
2022
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
Alvarez, MM; Biayna, J; Supek, F
Nature Communications
13
1
4520 -
-
2022
PerSVade: personalized structural variant detection in any species of interest
Schikora-Tamarit, MA; Gabaldón, T
Genome Biology
23
1
175 -
-
2022
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M; Lehner, B; Supek, F
Nature Communications
13
1
3724 -
-
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
Nature
607
7919
593 -
+
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
Nature
607
7919
593 -
+
2022
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer
3
9
1052 -
+
2022
BioExcel Building Blocks Workflows (BioBB-Wfs), an integrated web-based platform for biomolecular simulations
Bayarri, G; Andrio, P; Orozco, M; Gelpí, JL
Nucleic Acids Research
50
W1
W99 -
W107
2022
Chasing molecular glue degraders: screening approaches
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C
Chemical Society Reviews
51
13
5498 -
5517
2022
Chasing molecular glue degraders: screening approaches
Domostegui, A; Nieto-Barrado, L; Perez-Lopez, C; Mayor-Ruiz, C
Chemical Society Reviews
51
13
5498 -
5517
2022
Conformational ensemble of the TNF-derived peptide solnatide in solution
Martin-Malpartida, P; Arrastia-Casado, S; Farrera-Sinfreu, J; Lucas, R; Fischer, H; Fischer, B; Eaton, DC; Tzotzos, S; Macias, MJ
Computational And Structural Biotechnology Journal
20
-
2082 -
2090
2022
Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors
Willis, JR; Saus, E; Iraola-Guzman, S; Ksiezopolska, E; Cozzuto, L; Bejarano, LA; Andreu-Somavilla, N; Alloza-Trabado, M; Blanco, A; Puig-Sola, A; Broglio, E; Carolis, C; Ponomarenko, J; Hecht, J; Gabaldón, T
Npj Biofilms And Microbiomes
8
1
38 -
-
2022
Natural killer cells act as an extrinsic barrier for in vivo reprogramming
Melendez, E; Chondronasiou, D; Mosteiro, L; de Villarreal, JM; Fernandez-Alfara, M; Lynch, CJ; Grimm, D; Real, FX; Alcami, J; Climent, N; Pietrocola, F; Serrano, M
Development
149
8
dev200361 -
-
2022
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback
Tartour, K; Andriani, F; Folco, EG; Letkova, D; Schneider, R; Saidi, I; Sato, T; Welz, PS; Benitah, SA; Allier, C; Padmanabhan, K
Nature Structural & Molecular Biology
29
6
549 -
+
2022
Mutational signatures are markers of drug sensitivity of cancer cells
Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F
Nature Communications
13
1
2926 -
-
2022
Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation
Suñer, C; Sibilio, A; Martín, J; Castellazzi, CL; Reina, O; Dotu, I; Caballé, A; Rivas, E; Calderone, V; Díez, J; Nebreda, AR; Méndez, R
Elife
11
-
e75873 -
-
2022
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers, B; Eppink, B; James, MI; Cortina, C; Canellas-Socias, A; Boj, SF; Hernando-Momblona, X; Glodzik, D; Roovers, RC; van de Wetering, M; Bartelink-Clements, C; Zondag-van der Zande, V; Mateos, JG; Yan, K; Salinaro, L; Basmeleh, A; Fatrai, S; Maussang, D; van Bueren, JJL; Chicote, I; Serna, G; Cabellos, L; Ramirez, L; Nuciforo, P; Salazar, R;...
Nature Cancer
3
4
418 -
+
2022
The LEGO® brick road to open science and biotechnology
Boulter, E; Colombelli, J; Henriques, R; Feral, CC
Trends In Biotechnology
40
9
1073 -
1087
2022
Pathway-specific effects of ADSL deficiency on neurodevelopment
Dutto, I; Gerhards, J; Herrera, A; Souckova, O; Skopova, V; Smak, JA; Junza, A; Yanes, O; Boeckx, C; Burkhalter, MD; Zikanova, M; Pons, S; Philipp, M; Luders, J; Stracker, TH
Elife
11
-
e70518 -
-
2022
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Chondronasiou, D; Gill, D; Mosteiro, L; Urdinguio, RG; Berenguer, A; Aguilera, M; Durand, S; Aprahamian, F; Nirmalathasan, N; Abad, M; Martin-Herranz, DE; Otto-Attolini, CS; Prats, N; Kroemer, G; Fraga, MF; Reik, W; Serrano, M
Aging Cell
21
3
e13578 -
-
2022
Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development
Sibilio, A; Suñner, C; Fernández-Alfara, M; Martín, J; Berenguer, A; Calon, A; Chanes, V; Millanes-Romero, A; Fernández-Miranda, G; Batlle, E; Fernández, M; Méndez, R
Iscience
25
2
103790 -
-
2022
Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis
Pavinato, L; Villamor-Payà, M; Sanchiz-Calvo, M; Andreoli, C; Gay, M; Vilaseca, M; Arauz-Garofalo, G; Ciolfi, A; Bruselles, A; Pippucci, T; Prota, V; Carli, D; Giorgio, E; Radio, FC; Antona, V; Giuffrè, M; Ranguin, K; Colson, C; De Rubeis, S; Dimartino, P; Buxbaum, JD; Ferrero, GB; Tartaglia, M; Martinelli, S; Stracker, TH; Brusco, A
Journal Of Medical Genetics
59
2
170 -
179
2022