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Recerca

A l'avantguarda de la biomedicina

Publicacions de recerca

Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in App(NL-G-F), App(NL-F), and 3xTg-AD mouse models
Pauls, E; Bayod, S; Mateo, L; Alcalde, V; Juan-Blanco, T; Sanchez-Soto, M; Saido, TC; Saito, T; Berrenguer-Llergo, A; Attolini, CSO; Gay, M; de Oliveira, E; Duran-Frigola, M; Aloy, P
Genome Medicine
13
1
168 -
2021
Sub-centrosomal mapping identifies augmin-gamma TuRC as part of a centriole-stabilizing scaffold
Schweizer, N; Haren, L; Dutto, I; Viais, R; Lacasa, C; Merdes, A; Luders, J
Nature Communications
12
1
6042 -
2021
Conformational landscape of multidomain SMAD proteins
Gomes, T; Martin-Malpartida, P; Ruiz, L; Aragón, E; Cordeiro, TN; Macias, MJ
Computational And Structural Biotechnology Journal
19
5210 -
5224
2021
MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate
Gutierrez-Prat, N; Cubillos-Rojas, M; Canovas, B; Kuzmanic, A; Gupta, J; Igea, A; Llonch, E; Gaestel, M; Nebreda, AR
Proceedings Of The National Academy Of Sciences Of The United States Of America
118
29
e2024562118 -
2021
Probing allosteric regulations with coevolution-driven molecular simulations
Colizzi, F; Orozco, M
Science Advances
7
37
eabj0786 -
2021
Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
Viais, R; Fariña-Mosquera, M; Villamor-Payà, M; Watanabe, S; Palenzuela, L; Lacasa, C; Lüders, J
Elife
10
e67989
e67989 -
2021
In silico saturation mutagenesis of cancer genes
Muiños, F; Martínez-Jiménez, F; Pich, O; Gonzalez-Perez, A; Lopez-Bigas, N
Nature
596
7872
428 -
+
2021
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M
Developmental Cell
56
14
2043 -
+
2021
The ciliary impact of nonciliary gene mutations
Lovera, M; Lüders, J
Trends In Cell Biology
31
11
876 -
887
2021
Highlights from the 2016-2020 NEUBIAS training schools for Bioimage Analysts: A success story and key asset for analysts and life scientists
Martins GG; Cordelières FP; Miura K; Colombelli J; D'Antuono R; Golani O; Guiet R; Haase R; Klemm AH; Louveaux M; Paul-Gilloteaux P; Tinevez J-Y
F1000research
10
334 -
2021
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
Avgustinova, A; Laudanna, C; Pascual-García, M; Rovira, Q; Djurec, M; Castellanos, A; Urdiroz-Urricelqui, U; Marchese, D; Prats, N; Van Keymeulen, A; Heyn, H; Vaquerizas, JM; Benitah, SA
Cell Stem Cell
28
10
1790 -
+
2021
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
Scholes, NS; Mayor-Ruiz, C; Winter, GE
Cell Chemical Biology
28
7
1048 -
1060
2021
Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
Torres, AG; Rodríguez-Escribà, M; Marcet-Houben, M; Vieira, HGS; Camacho, N; Catena, H; Recio, MM; Rafels-Ybern, A; Reina, O; Torres, FM; Pardo-Saganta, A; Gabaldón, T; Novoa, EM; de Pouplana, LR
Nucleic Acids Research
49
12
7011 -
7034
2021
Bioactivity descriptors for uncharacterized chemical compounds
Bertoni, M; Duran-Frigola, M; Badia-i-Mompel, P; Pauls, E; Orozco-Ruiz, M; Guitart-Pla, O; Alcalde, V; Diaz, VM; Berenguer-Llergo, A; Brun-Heath, I; Villegas, N; de Herreros, AG; Aloy, P
Nature Communications
12
1
3932 -
-
2021
Bioimage analysis workflows: Community resources to navigate through a complex ecosystem
Paul-Gilloteaux P; Tosi S; Hériché JK; Gaignard A; Ménager H; Marée R; Baecker V; Klemm A; Kalaš M; Zhang C; Miura K; Colombelli J
F1000research
10
320 -
2021
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
Serra, SA; Stojakovic, P; Amat, R; Rubio-Moscardo, F; Latorre, P; Seisenbacher, G; Canadell, D; Böttcher, R; Aregger, M; Moffat, J; de Nadal, E; Valverde, MA; Posas, F
Proceedings Of The National Academy Of Sciences Of The United States Of America
118
23
e2025013118 -
2021
Environmental robustness of the global yeast genetic interaction network
Costanzo, M; Hou, J; Messier, V; Nelson, J; Rahman, M; VanderSluis, B; Wang, W; Pons, C; Ross, C; Usaj, M; San Luis, BJ; Shuteriqi, E; Koch, EN; Aloy, P; Myers, CL; Boone, C; Andrews, B
Science
372
6542
589 -
+
2021
Impact of DNA methylation on 3D genome structure
Buitrago, D; Labrador, M; Arcon, JP; Lema, R; Flores, O; Esteve-Codina, A; Blanc, J; Villegas, N; Bellido, D; Gut, M; Dans, PD; Heath, SC; Gut, IG; Heath, IB; Orozco, M
Nature Communications
12
1
3243 -
2021
Protamine characterization by top-down proteomics: Boosting proteoform identification with dbscan
Arauz-Garofalo, G; Jodar, M; Vilanova, M; Rodriguez, AD; Castillo, J; Soler-Ventura, A; Oliva, R; Vilaseca, M; Gay, M
Proteomes
9
2
21 -
2021
The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health
Sun-Wang, JL; Yarritu-Gallego, A; Ivanova, S; Zorzano, A
Trends In Endocrinology And Metabolism
32
8
594 -
608
2021
Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins
Freier, R; Aragon, E; Pluta, R; Martin-Malpartida, P; Ruiz, L; Condeminas, M; Gonzalez, C; Macias, MJ
Iucrj
8
Pt 2
281 -
294
2021
Dissection of two routes to naive pluripotency using different kinase inhibitors
Martinez-Val, A; Lynch, CJ; Calvo, I; Ximenez-Embun, P; Garcia, F; Zarzuela, E; Serrano, M; Munoz, J
Nature Communications
12
1
1863 -
2021
Report The Upd3 cytokine couples inflammation to maturation defects in Drosophila
Romao, D; Muzzopappa, M; Barrio, L; Milan, M
Current Biology
31
8
1780 -
+
2021
Furan warheads for covalent trapping of weak protein-protein interactions: cross-linking of thymosin beta 4 to actin
Miret-Casals, L; Vannecke, W; Hoogewijs, K; Arauz-Garofalo, G; Gay, M; Díaz-Lobo, M; Vilaseca, M; Ampe, C; Van Troys, M; Madder, A
Chemical Communications
57
49
6054 -
6057
2021
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo
Climent-Cantó, P; Carbonell, A; Tamirisa, S; Henn, L; Pérez-Montero, S; Boros, IM; Azorín, F
Open Biology
11
5
200408 -
2021
Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19
Bernad, R; Lynch, CJ; Urdinguio, RG; Attolini, CSO; Fraga, MF; Serrano, M
Cells
10
4
876 -
2021
Quality control of protein reagents for the improvement of research data reproducibility
de Marco, A; Berrow, N; Lebendiker, M; Garcia-Alai, M; Knauer, SH; Lopez-Mendez, B; Matagne, A; Parret, A; Remans, K; Uebel, S; Raynal, B
Nature Communications
12
1
2795 -
2795
2021
Intrinsically disordered proteins and biomolecular condensates as drug targets
Biesaga, M; Frigolé-Vivas, M; Salvatella, X
Current Opinion In Chemical Biology
62
90 -
100
2021
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
Biayna, J; Garcia-Cao, I; Alvarez, MM; Salvadores, M; Espinosa-Carrasco, J; McCullough, M; Supek, F; Stracker, TH
Plos Biology
19
3
e3001176 -
2021
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
Yero, D; Díaz-Lobo, M; Costenaro, L; Conchillo-Solé, O; Mayo, A; Ferrer-Navarro, M; Vilaseca, M; Gibert, I; Daura, X
Commun Biol
4
1
448 -
2021
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ
Nature Communications
12
1
1869 -
-
2021
Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin
Dekan, Z; Kremsmayr, T; Keov, P; Godin, M; Teakle, N; Dürrauer, L; Xiang, H; Gharib, D; Bergmayr, C; Hellinger, R; Gay, M; Vilaseca, M; Kurzbach, D; Albericio, F; Alewood, PF; Gruber, CW; Muttenthaler, M
Chemical Science
12
11
4057 -
4062
2021
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells
Pekmezovic, M; Hovhannisyan, H; Gresnigt, MS; Iracane, E; Oliveira-Pacheco, J; Siscar-Lewin, S; Seemann, E; Qualmann, B; Kalkreuter, T; Müller, S; Kamradt, T; Mogavero, S; Brunke, S; Butler, G; Gabaldón, T; Hube, B
Nature Microbiology
6
5
643 -
+
2021
Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells
Giannios, P; Casanova, J
Plos Genetics
17
2
e1009362 -
2021
MosaicExplorerJ: Interactive stitching of terabyte-size tiled datasets from lightsheet microscopy
Tosi S; Bardia L; Barallobre MJ; Muñoz-Barrutia A; Soto-Montenegro ML; Colombelli J
F1000research
9
1 -
15
2021
Regulation of biomolecular condensate dynamics by signaling
Garcia-Cabau, C; Salvatella, X
Current Opinion In Cell Biology
69
111 -
119
2021
Diversity and versatility of p38 kinase signalling in health and disease
Canovas, B; Nebreda, AR
Nature Reviews Molecular Cell Biology
22
5
346 -
366
2021
Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
Ruiz, L; Kaczmarska, Z; Gomes, T; Aragon, E; Torner, C; Freier, R; Baginski, B; Martin-Malpartida, P; Garrido, ND; Marquez, JA; Cordeiro, TN; Pluta, R; Macias, MJ
Computational And Structural Biotechnology Journal
19
632 -
646
2021
Centrosomes in asymmetric cell division
Gonzalez, C
Current Opinion In Structural Biology
66
178 -
182
2021
Timing the origin of eukaryotic cellular complexity with ancient duplications
Vosseberg, J; van Hooff, JJE; Marcet-Houben, M; van Vlimmeren, A; van Wijk, LM; Gabaldón, T; Snel, B
Nature Ecology & Evolution
5
1
- -
-
2021
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
Bauer S, Heinrich MC, George S, Zalcberg JR, Serrano C, Gelderblom H, Jones RL, Attia S, D’Amato G, Chi P, Reichardt P, Meade J, Su Y, Ruiz-Soto R, Blay JY,
von Mehren M, Schöffski P.
Clin Cancer Res
6333 -
6342
2021
E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor
Alfonso García-Valverde, Jordi Rosell, Sergi Sayols, David Gómez-Peregrina, Daniel F Pilco-Janeta, Iván Olivares-Rivas, Enrique de Álava, Joan Maurel, Jordi Rubió-Casadevall, Anna Esteve, Marta Gut, Claudia Valverde, Jordi Barretina, Joan Carles, George D Demetri, Jonathan A Fletcher, Joaquín Arribas & César Serrano
Oncogene
2021
A gene–environment-induced epigenetic program initiates tumorigenesis
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan L, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW.
Nature
2021
Circadian Regulation of Adult Stem Cell Homeostasis and Aging
Benitah, SA; Welz, PS
Cell Stem Cell
26
6
817 -
831
2020
BIAFLOWS: A Collaborative Framework to Reproducibly Deploy and Benchmark Bioimage Analysis Workflows
Rubens, U; Mormont, R; Paavolainen, L; Backer, V; Pavie, B; Scholz, LA; Michiels, G; Maska, M; Unay, D; Ball, G; Hoyoux, R; Vandaele, R; Golani, O; Stanciu, SG; Sladoje, N; Paul-Gilloteaux, P; Maree, R; Tosi, S
Patterns
1
3
100040 -
2020
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A
Nature Cancer
1
1
122 -
+
2020
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome
Testoni, G; Olmeda, B; Duran, J; López-Rodríguez, E; Aguilera, M; Hernández-Alvarez, MI; Prats, N; Pérez-Gil, J; Guinovart, JJ
Human Molecular Genetics
29
21
3554 -
3565
2020
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase
Zimmermann, F; Serna, M; Ezquerra, A; Fernandez-Leiro, R; Llorca, O; Luders, J
Science Advances
6
51
eabe0894 -
-
2020