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Recerca

A l'avantguarda de la biomedicina

Publicacions de recerca

Redox proteomics reveal a role for peroxiredoxinylation in stress protection
Seisenbacher, Gerhard; Nakic, Zrinka Raguz; Borràs, Eva; Sabidó, Eduard; Sauer, Uwe; de Nadal, Eulalia; Posas, Francesc
Cell Reports
44
2
115224 -
-
2025
Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD
Garcia-Cabau C; Bartomeu A; Tesei G; Cheung KC; Pose-Utrilla J; Picó S; Balaceanu A; Duran-Arqué B; Fernández-Alfara M; Martín J; De Pace C; Ruiz-Pérez L; García J; Battaglia G; Lucas JJ; Hervás R; Lindorff-Larsen K; Méndez R; Salvatella X
Nature
637
8045
496 -
503
2025
TGF-β and RAS jointly unmask primed enhancers to drive metastasis
Lee, Jun Ho; Sánchez-Rivera, Francisco J.; He, Lan; Basnet, Harihar; Chen, Fei Xavier; Spina, Elena; Li, Liangji; Torner, Carles; Chan, Jason E.; Yarlagadda, Dig Vijay Kumar; Park, Jin Suk; Sussman, Carleigh; Rudin, Charles M.; Lowe, Scott W.; Tammela, Tuomas; Macias, Maria J.; Koche, Richard P.; Massagué, Joan
Cell
187
22
6182 -
6199.e29
2024
Metabolic homeostasis of tissue macrophages across the lifespan
Wculek, Stefanie K. (#); Forisch, Stephan; Miguel, Verónica; Sancho, David (#)
(#) Corresponding author
Trends In Endocrinology And Metabolism
-
-
- -
-
2024
Harnessing dendritic cell metabolism for healthy ageing: reducing the risk of cardiovascular disease?
Wculek, SK
European Heart Journal
45
27
2355 -
2357
2024
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O'Sullivan, AM; Davtyan, A; Samudio, B; Thomas, B; Worley, B; Butler, B; Laggner, C; Thayer, D; Moharreri, E; Friedland, G; Truong, H; van den Bedem, H; Ng, HL; Stafford, K; Sarangapani, K; Giesler, K; Ngo, L; Mysinger, M; Ahmed, M; Anthis, NJ; Henriksen, N; Gniewek, P;...
Scientific Reports
14
1
7526 -
-
2024
Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues
Sánchez-Guixé, Mònica; Muiños, Ferran; Pinheiro-Santin, Morena; González-Huici, Víctor; Rodriguez-Hernandez, Carlos J.; Avgustinova, Alexandra; Lavarino, Cinzia; González-Pérez, Abel; Mora, Jaume; López-Bigas, Núria
Cancer Discovery
-
-
OF1 -
OF12
2024
Mechanisms of metastatic colorectal cancer
Cañellas-Socias, Adrià; Sancho, Elena; Batlle, Eduard
Nature Reviews Gastroenterology & Hepatology
21
9
609 -
625
2024
Innovating in a bioimaging core through instrument development
Munck, S; De Bo, C; Cawthorne, C; Colombelli, J
Journal Of Microscopy
294
3
319 -
337
2024
Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells
Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C
Nucleic Acids Research
52
6
3375 -
3389
2024
Dendritic cells as orchestrators of anticancer immunity and immunotherapy
Heras-Murillo, I; Adán-Barrientos, I; Galán, M; Wculek, SK (#) ; Sancho, D (#)
(#) Corresponding author
Nature Reviews Clinical Oncology
21
4
257 -
277
2024
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib S; López-Domínguez JA; Lalinde-Gutiérrez M; Prats N; Marin I; Boix O; García-Garijo A; Meyer K; Muñoz MI; Aguilera M; Mateo L; Stephan-Otto Attolini C; Llanos S; Pérez-Ramos S; Escorihuela M; Al-Shahrour F; Cash TP; Tchkonia T; Kirkland JL; Abad M; Gros A; Arribas J; Serrano M
Nature Cancer
5
3
448 -
462
2024
Urease-powered nanobots for radionuclide bladder cancer therapy
Simo, C; Serra-Casablancas, M; Hortelao, AC; Di Carlo, V; Guallar-Garrido, S; Plaza-Garcia, S; Rabanal, RM; Ramos-Cabrer, P; Yaguee, B; Aguado, L; Bardia, L; Tosi, S; Gomez-Vallejo, V; Martin, A; Patino, T; Julian, E; Colombelli, J; Llop, J; Sanchez, S
Nature Nanotechnology
19
-
554 -
564
2024
Hotspot propensity across mutational processes
Arnedo-Pac C, Muiños F, Gonzalez-Perez A, Lopez-Bigas N
Molecular Systems Biology
20
1
6 -
27
2024
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, MA; Gabaldón, T
Nature Microbiology
9
1
284 -
307
2024
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C
Angewandte Chemie (International Ed. Print)
63
12
e202316730 -
e202316730
2024
Perturbation-driven transcriptional heterogeneity impacts cell fitness
Nadal-Ribelles, M; Solé, C; Diez-Villanueva, A; Stephan-Otto Attolini, C; Matas, Y; Steinmetz, L; de Nadal, E; Posas F.
2024
MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis
Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR
Nature Cell Biology
25
12
1833 -
1847
2023
Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity
Marin, I; Boix, O; Garcia-Garijo, A; Sirois, I; Caballe, A; Zarzuela, E; Ruano, I; Attolini, CSO; Prats, N; López-Domínguez, JA; Kovatcheva, M; Garralda, E; Muñoz, J; Caron, E; Abad, M; Gros, A; Pietrocola, F; Serrano, M
Cancer Discovery
13
2
410 -
431
2023
Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
Pous, J; Baginski, B; Martin-Malpartida, P; González, L; Scarpa, M; Aragon, E; Ruiz, L; Mees, RA; Iglesias-Fernández, J; Orozco, M; Nebreda, AR; Macias, MJ
Nature Communications
14
1
7920 -
-
2023
Origin of fungal hybrids with pathogenic potential from warm seawater environments
del Olmo, V; Mixao, V; Fotedar, R; Saus, E; Al Malki, A; Ksiezopolska, E; Nunez-Rodriguez, JC; Boekhout, T; Gabaldón, T
Nature Communications
14
1
6919 -
-
2023
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M
Nature Metabolism
5
11
1911 -
1930
2023
Roastgsa: a comparison of rotation-based scores for gene set enrichment analysis
Caballé-Mestres, A; Berenguer-Llergo, A; Attolini, CSO
Bmc Bioinformatics
24
1
408 -
-
2023
A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing
Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M
Nature Cell Biology
25
11
1590 -
1599
2023
Chromosomal instability-induced cell invasion through caspase-driven DNA damage
Barrio, L; Gaspar, AE; Muzzopappa, M; Ghosh, K; Romao, D; Clemente-Ruiz, M; Milan, M
Current Biology
33
20
S0960 -
4
2023
Expansion microscopy of the chick embryo neural tube to overcome molecular crowding at the centrosomes-cilia
Wilmerding, A; Espana-Bonilla, P; Giakoumakis, NN; Saade, M
Star Protocols
4
1
101997 -
-
2023
Neurogenesis redirects β-catenin from adherens junctions to the nucleus to promote axonal growth
Herrera, A; Menendez, A; Ochoa, A; Bardia, L; Colombelli, J; Pons, S
Development
150
16
dev201651 -
-
2023
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy
Redondo-Munoz, M; Rodriguez-Baena, FJ; Aldaz, P; Caballe-Mestres, A; Moncho-Amor, V; Otaegi-Ugartemendia, M; Carrasco-Garcia, E; Olias-Arjona, A; Lasheras-Otero, I; Santamaria, E; Bocanegra, A; Chocarro, L; Grier, A; Dzieciatkowska, MM; Bigas, C; Martin, J; Urdiroz-Urricelqui, U; Marzo, F; Santamaria, E; Kochan, G; Escors, D; Larrayoz, IM; Heyn,...
Nature Metabolism
5
9
1544 -
+
2023
scKINETICS: inference of regulatory velocity with single-cell transcriptomics data
Burdziak, C; Zhao, CJ; Haviv, D; Alonso-Curbelo, D; Lowe, SW; Pe'er, D
Bioinformatics
39
39 Suppl 1
i394 -
i403
2023
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L
Science
380
6651
eadh9351 -
eadh9351
2023
Targeting lymphoid-derived IL-17 signaling to delay skin aging
Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA
Nature Aging
3
6
688 -
+
2023
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR
Nature Communications
14
1
3318 -
-
2023
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M
Nucleic Acids Research
51
10
4713 -
4725
2023
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D
Science
380
6645
597 -
+
2023
Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation
Ward JA, Perez-Lopez C, Mayor-Ruiz C
Chembiochem
24
10
e202300163 -
e202300163
2023
Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation
Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C
Chembiochem
24
10
- -
-
2023
The P4-ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast
Pazos, I; Puig-Tintó, M; Betancur, L; Cordero, J; Jiménez-Menéndez, N; Abella, M; Hernández, AC; Duran, AG; Adachi-Fernández, E; Belmonte-Mateos, C; Sabido-Bozo, S; Tosi, S; Nezu, A; Oliva, B; Colombelli, J; Graham, TR; Yoshimori, T; Muñiz, M; Hamasaki, M; Gallego, O
Embo Reports
24
5
e56134 -
-
2023
Correlated motions in DNA: beyond base-pair step models of DNA flexibility
López-Güell, K; Battistini, F; Orozco, M
Nucleic Acids Research
51
6
2633 -
2640
2023
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress
Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R
Embo Journal
42
9
e111494 -
-
2023
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Maus, M; López-Polo, V; Mateo, L; Lafarga, M; Aguilera, M; De Lama, E; Meyer, K; Sola, A; Lopez-Martinez, C; López-Alonso, I; Guasch-Piqueras, M; Hernandez-Gonzalez, F; Chaib, S; Rovira, M; Sanchez, M; Faner, R; Agusti, A; Diéguez-Hurtado, R; Ortega, S; Manonelles, A; Engelhardt, S; Monteiro, F; Attolini, CSO; Prats, N; Albaiceta, G; Cruzado,...
Nature Metabolism
-
-
- -
-
2023
Transient and DNA-free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis
Navaridas, R; Vidal-Sabanés, M; Ruiz-Mitjana, A; Perramon-Güell, A; Megino-Luque, C; Llobet-Navas, D; Matias-Guiu, X; Egea, J; Encinas, M; Bardia, L; Colombelli, J; Dolcet, X
Cancer Communications
43
5
620 -
624
2023
Copy number footprints of platinum-based anticancer therapies
Gonzalez, S; Lopez-Bigas, N; Gonzalez-Perez, A
Plos Genetics
19
2
e1010634 -
-
2023
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
Mensah, MA; Niskanen, H; Magalhaes, AP; Basu, S; Kircher, M; Sczakiel, HL; Reiter, AMV; Elsner, J; Meinecke, P; Biskup, S; Chung, BHY; Dombrowsky, G; Eckmann-Scholz, C; Hitz, MP; Hoischen, A; Holterhus, PM; Hülsemann, W; Kahrizi, K; Kalscheuer, VM; Kan, A; Krumbiegel, M; Kurth, I; Leubner, J; Longardt, AC; Moritz, JD; Najmabadi, H; Skipalova, K;...
Nature
614
7948
564 -
+
2023
pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs
Serrano-Chacon, I; Mir, B; Cupellini, L; Colizzi, F; Orozco, M; Escaja, N; Gonzalez, C
Journal Of The American Chemical Society
145
6
3696 -
3705
2023
Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein
Machón, C; Ruiz-Masó, JA; Amodio, J; Boer, DR; Bordanaba-Ruiseco, L; Bury, K; Konieczny, I; del Solar, G; Coll, M
Nucleic Acids Research
51
3
1458 -
1472
2023
A proteome-scale map of the SARS-CoV-2-human contactome
Kim, DK; Weller, B; Lin, CW; Sheykhkarimli, D; Knapp, JJ; Dugied, G; Zanzoni, A; Pons, C; Tofaute, MJ; Maseko, SB; Spirohn, K; Laval, F; Lambourne, L; Kishore, N; Rayhan, A; Sauer, M; Young, V; Halder, H; Marín-de la Rosa, N; Pogoutse, O; Strobel, A; Schwehn, P; Li, RJ; Rothballer, ST; Altmann, M; Cassonnet, P; Coté, AG; Vergara, LE; Hazelwood,...
Nature Biotechnology
41
1
140 -
149
2023
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis
Sabaté-Pérez, A; Romero, M; Sànchez-Fernàndez-de-Landa, P; Carobbio, S; Mouratidis, M; Sala, D; Engel, P; Villena, JA; Virtue, S; Vidal-Puig, A; Palacín, M; Testar, X; Zorzano, A
Autophagy
19
3
904 -
925
2023
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Wculek SK#, Heras-Murillo I, Mastrangelo A, Mañanes D, Galán M, Miguel V, Curtabbi A, Barbas, C, Chandel NS, Enríquez JA, Lamas S, Sancho D#
(#) Corresponding author
Immunity
(56:1-15)
2023