Publicaciones sobre Investigación

Title

Year

Research Group

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice

Rodríguez-Matellán, A; Alcazar, N; Hernández, F; Serrano, M; Avila, J

Stem Cell Reports

1056 -

1066

2020

The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing

Sun-Wang, JL; Ivanova, S; Zorzano, A

Ageing Research Reviews

101203

101203 -

2020

Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand

Martinez-Crespo, Luis; Liang Sun-Wang, Jia; Felipe Sierra, Andres; Aragay, Gemma; Errasti-Murugarren, Ekaitz; Bartoccioni, Paola; Palacin, Manuel; Ballester, P

Chem

3054 -

3070

2020

A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression

Torras-Llort, M; Medina-Giró, S; Escudero-Ferruz, P; Lipinszki, Z; Moreno-Moreno, O; Karman, Z; Przewloka, MR; Azorín, F

Commun Biol

454 -

2020

The evolution of relapse of adult T cell acute lymphoblastic leukemia

Sentís, I; Gonzalez, S; Genescà, E; García-Hernández, V; Muiños, F; Gonzalez, C; López-Arribillaga, E; Gonzalez, J; Fernandez-Ibarrondo, L; Mularoni, L; Espinosa, L; Bellosillo, B; Ribera, JM; Bigas, A; Gonzalez-Perez, A; Lopez-Bigas, N

Genome Biology

284 -

2020

ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Urosevic, J; Blasco, MT; Llorente, A; Bellmunt, A; Berenguer-Llergo, A; Guiu, M; Cañellas, A; Fernandez, E; Burkov, I; Clapés, M; Cartanà, M; Figueras-Puig, C; Batlle, E; Nebreda, AR; Gomis, RR

Cancer Research

4668 -

4680

2020

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

Mateo, L; Duran-Frigola, M; Gris-Oliver, A; Palafox, M; Scaltriti, M; Razavi, P; Chandarlapaty, S; Arribas, J; Bellet, M; Serra, V; Aloy, P

Genome Medicine

78 -

2020

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Pittis, AA; Goh, V; Cebrian-Serrano, A; Wettmarshausen, J; Perocchi, F; Gabaldón, T

Nature Communications

4031 -

2020

A compendium of mutational cancer driver genes

Martínez-Jiménez, F; Muiños, F; Sentís, I; Deu-Pons, J; Reyes-Salazar, I; Arnedo-Pac, C; Mularoni, L; Pich, O; Bonet, J; Kranas, H; Gonzalez-Perez, A; Lopez-Bigas, N

Nature Reviews Cancer

555 -

572

2020

Manipulating the Mediator complex to induce naïve pluripotency

Lynch, CJ; Bernad, R; Calvo, I; Serrano, M

Experimental Cell Research

395

112215 -

2020

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Mas-Ponte, D; Supek, F

Nature Genetics

958 -

2020

Induction of lysosome membrane permeabilization as a therapeutic strategy to target pancreatic cancer stem cells

Cash, TP; Alcalá, S; Rico-Ferreira, MD; Hernández-Encinas, E; García, J; Albarrán, MI; Valle, S; Muñoz, J; Martínez-González, S; Blanco-Aparicio, C; Pastor, J; Serrano, M; Sainz, B

Cancers

1790 -

2020

Probing the Kinetic and Thermodynamic Fingerprints of Anti-EGF Nanobodies by Surface Plasmon Resonance

Guardiola, S; Varese, M; Taulés, M; Díaz-Lobo, M; García, J; Giralt, E

Pharmaceuticals

134 -

2020

Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns

Salvadores, M; Fuster-Tormo, F; Supek, F

Science Advances

eaba1862 -

2020

Self-Eating for Muscle Fitness: Autophagy in the Control of Energy Metabolism

Sebastián, D; Zorzano, A

Developmental Cell

268 -

281

2020

Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

Donoghue, C; Cubillos-Rojas, M; Gutierrez-Prat, N; Sanchez-Zarzalejo, C; Verdaguer, X; Riera, A; Nebreda, AR

European Journal Of Medicinal Chemistry

201

112451

112451 -

2020

The NEUBIAS Gateway: A hub for bioimage analysis methods and materials

Miura K; Cimini BA; Nørrelykke SF; Louveaux M; Sladoje N; Paul-Gilloteaux P; Colombelli J

F1000research

613 -

2020

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer

Dziubanska-Kusibab, PJ; Berger, H; Battistini, F; Bouwman, BAM; Iftekhar, A; Katainen, R; Cajuso, T; Crosetto, N; Orozco, M; Aaltonen, LA; Meyer, TF

Nature Medicine

1063 -

2020

Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P

Nature Biotechnology

1087 -

2020

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Morral, C; Stanisavljevic, J; Hernando-Momblona, X; Mereu, E; Alvarez-Varela, A; Cortina, C; Stork, D; Slebe, F; Turon, G; Whissell, G; Sevillano, M; Merlos-Suárez, A; Casanova-Martí, A; Moutinho, C; Lowe, SW; Dow, LE; Villanueva, A; Sancho, E; Heyn, H; Batlle, E

Cell Stem Cell

845 -

2020

LOBSTER: an environment to design bioimage analysis workflows for large and complex fluorescence microscopy data

Tosi, S; Bardia, L; Filgueira, MJ; Calon, A; Colombelli, J

Bioinformatics

2634 -

2635

2020

A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress

Viéitez, C; Martínez-Cebrián, G; Solé, C; Böttcher, R; Potel, CM; Savitski, MM; Onnebo, S; Fabregat, M; Shilatifard, A; Posas, F; de Nadal, E

Nucleic Acids Research

3455 -

3475

2020

The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer

Pascual, R; Martín, J; Salvador, F; Reina, O; Chanes, V; Millanes-Romero, A; Suñer, C; Fernández-Miranda, G; Bartomeu, A; Huang, YS; Gomis, RR; Méndez, R

Science Advances

eaax3868 -

2020

Hog1 activation delays mitotic exit via phosphorylation of Net1

Tognetti, S; Jiménez, J; Viganò, M; Duch, A; Queralt, E; de Nadal, E; Posas, F

Proceedings Of The National Academy Of Sciences Of The United States Of America

117

8924 -

8933

2020

Imaging the Cell Morphological Response to 3D Topography and Curvature in Engineered Intestinal Tissues

Altay, G; Tosi, S; García-Díaz, M; Martínez, E

Frontiers In Bioengineering And Biotechnology

294

294 -

00294

2020

A reference map of the human binary protein interactome

Luck, K; Kim, DK; Lambourne, L; Spirohn, K; Begg, BE; Bian, WT; Brignall, R; Cafarelli, T; Campos-Laborie, FJ; Charloteaux, B; Choi, D; Cote, AG; Daley, M; Deimling, S; Desbuleux, A; Dricot, A; Gebbia, M; Hardy, MF; Kishore, N; Knapp, JJ; Kovacs, IA; Lemmens, I; Mee, MW; Mellor, JC; Pollis, C; Pons, C; Richardson, AD; Schlabach, S; Teeking, B; Yadav, A; Babor, M; Balcha, D; Basha, O; Bowman-Colin, C; Chin, SF; Choi, SG; Colabella, C; Coppin, G; D'Amata, C; De Ridder, D; De Rouck, S; Duran-Frigola, M; Ennajdaoui, H; Goebels, F; Goehring, L; Gopal, A; Haddad, G; Hatchi, E; Helmy, M; Jacob, Y; Kassa, Y; Landini, S; Li, RJ; van Lieshout, N; MacWilliams, A; Markey, D; Paulson, JN; Rangarajan, S; Rasla, J; Rayhan, A; Rolland, T; San-Miguel, A; Shen, Y; Sheykhkarimli, D; Sheynkman, GM; Simonovsky, E; Tasan, M; Tejeda, A; Tropepe, V; Twizere, JC; Wang, Y; Weatheritt, RJ; Weile, J; Xia, Y; Yang, XP; Yeger-Lotem, E; Zhong, Q; Aloy, P; Bader, GD; Rivas, JDL; Gaudet, S; Hao, T; Rak, J; Tavernier, J; Hill, DE; Vidal, M; Roth, FP; Calderwood, MA

Nature

580

7803

402 -

2020

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Sati, S; Bonev, B; Szabo, Q; Jost, D; Bensadoun, P; Serra, F; Loubiere, V; Papadopoulos, GL; Rivera-Mulia, JC; Fritsch, L; Bouret, P; Castillo, D; Gelpi, JLI; Orozco, M; Vaillant, C; Pellestor, F; Bantignies, F; Marti-Renom, MA; Gilbert, DM; Lemaitre, JM; Cavalli, G

Molecular Cell

522 -

2020

Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry

Sridhar, A; Farr, SE; Portella, G; Schlick, T; Orozco, M; Collepardo-Guevara, R

Proceedings Of The National Academy Of Sciences Of The United States Of America

117

7216 -

7224

2020

Synthesis and Application of 3-Bromo-1,2,4,5-Tetrazine for Protein Labeling to Trigger Click-to-Release Biorthogonal Reactions

Ros, E; Bellido, M; Verdaguer, X; de Pouplana, LR; Riera, A

Bioconjugate Chemistry

933 -

938

2020

P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis

Cabré, A; Riera, A; Verdaguer, X

Accounts Of Chemical Research

676 -

689

2020

Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols

Cabre, A; Rafael, S; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A

Angewandte Chemie (International Ed. Print)

7521 -

7527

2020

From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy

Kennel, P; Dichamp, J; Barreau, C; Guissard, C; Teyssedre, L; Rouquette, J; Colombelli, J; Lorsignol, A; Casteilla, L; Plouraboué, F

Plos Computational Biology

e1007322 -

2020

A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level

Walther, J; Dans, PD; Balaceanu, A; Hospital, A; Bayarri, G; Orozco, M

Nucleic Acids Research

e29 -

2020

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers

Barrio, L; Milán, M

Developmental Cell

659 -

2020

The mitochondrial tRNA conundrum

de Pouplana, LR

Nature Reviews Molecular Cell Biology

361 -

361

2020

Gene gain and loss across the metazoan tree of life

Fernández, R; Gabaldón, T

Nature Ecology & Evolution

524 -

533

2020

The embryonic linker histone dBigH1 alters the functional state of active chromatin

Climent-Cantó, P; Carbonell, A; Tatarski, M; Reina, O; Bujosa, P; Font-Mateu, J; Bernués, J; Beato, M; Azorín, F

Nucleic Acids Research

4147 -

4160

2020

Requirement for epithelial p38α in KRAS-driven lung tumor progression

Vitos-Faleato, J; Real, SM; Gutierrez-Prat, N; Villanueva, A; Llonch, E; Drosten, M; Barbacid, M; Nebreda, AR

Proceedings Of The National Academy Of Sciences Of The United States Of America

117

2588 -

2596

2020

Characterization of Human Sperm Protamine Proteoforms through a Combination of Top-Down and Bottom-Up Mass Spectrometry Approaches

Soler-Ventura, A; Gay, M; Jodar, M; Vilanova, M; Castillo, J; Arauz-Garofalo, G; Villarreal, L; Ballescà, JL; Vilaseca, M; Oliva, R

Journal Of Proteome Research

221 -

237

2020

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice

Marín-Aguilar F; Lechuga-Vieco AV

Aging Cell

2020

Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Lechuga-Vieco, AV

Sci. Adv

2020

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Nicolás-Ávila, JA*; Lechuga-Vieco, AV*

Cell

2020

Rational discovery of molecular glue degraders via scalable chemical profiling

Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E

Nat Chem Bio

2020

Dendritic cells in cancer immunology and immunotherapy

Wculek SK*, Cueto FJ*, Mujal AM, Melero I, Krummel MF, Sancho D#
(#) Corresponding author; (*) these authors contributed equally

Nature Reviews Immunology

20(1):7-24

2020

Early neutrophil responses to chemical carcinogenesis shape long-term lung cancer susceptibility

Wculek SK*, Bridgeman VL*, Peakman F, Malanchi I#
(#) Corresponding author; (*) these authors contributed equally

iScience

23(7):101277

2020

Senolytic CAR T cells reverse senescence-associated pathologies

Amor C*, Feucht J*, Leibold J*, Ho Y-J, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, et al, Sadelain M, Lowe SW.
(*) these authors contributed equally

Nature

2020

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

Paz Zafra M, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E and Dow LE.

Cancer Discovery

2020

Rational discovery of molecular glue degraders via scalable chemical profiling

Nat Chem Bio

2020