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Molecular Modelling and Bioinformatics News

Scientific
A new tool to predict nucleosome position
Media mentions
New simplified DNA model for advanced computational simulations - PHYS
Scientific
New simplified DNA model for advanced computational simulations
Institutional
XNA-HUB, platform to boost therapeutic modified oligonucleotides
Scientific
BioExcel-CV19: A Breakthrough in Understanding COVID-19 Proteins
Scientific
A new inactive form of p38a protein discovered
Institutional
IRB Barcelona joins the digital research infrastructure EBRAINS as new associate member
Scientific
Simulation tools drive the new generation of therapies based on gene silencing
Institutional
IRB Barcelona leads an ambitious European project to create the first database of molecular dynamics
Scientific
A new model predicts the flexibility of DNA movement at the molecular scale
Scientific
Researchers identify DNA sequences that modify their structure according to the environment
Media mentions
Una nueva técnica captura cómo los genes se pliegan y funcionan a una resolución sin precedentes - BioTech
Scientific
Researchers capture how genes fold and work at unprecedented resolution
Scientific
Biomolecular simulations closer to the scientific community with BioExcel Building Blocks Workflows
PIE
Scientific
A new method to understand protein dynamics and the regulation of cellular processes
DNA methylation has an intrinsic effect on 3D genome structure
Scientific
Regulation of the genome affects its 3D structure
Scientific
A role of colibactin-producing E. coli in carcinogenesis
Modesto Orozco during the award ceremony
Innovation
The spin-off Nostrum Biodiscovery wins the 2019 Senén Vilaró Prize
”la Caixa” Fellowship award ceremony
Institutional
Four research groups at IRB Barcelona among the beneficiaries of ”la Caixa” projects
The DNAzyme 9DB1, whose catalytically active structure and reaction mechanism was unknown, makes use of a mechanism involving two ions, similar to that used by natural enzymes (J. Aranda, IRB Barcelona).
Scientific
A study from IRB Barcelona describes the reaction mechanism of DNAzymes and opens new propsects in the field of biocatalysers
Scientific
A study makes a significant contribution to progress in gene therapy efficiency by identifying the source of asymmetry in RNA · DNA hybrids
Illustrated view of the different conformations adopted by a flexible small molecule. Colours represent different ensembles of conformations.
Scientific
Molecular dynamics simulation provides a “single-interaction” perspective to protein dynamics and drug binding
Structure of EGFR. Purple indicates the region recognised by mAB806. Laura Orellana.
Media mentions
New approaches for the treatment of cancer
Structure of EGFR. Purple indicates the region recognised by mAB806. Laura Orellana.
Scientific
Researchers discover the mechanism of action of an antitumour drug used for the treatment of glioblastoma
Source: La Diaria
Media mentions
Matrix, DNA and computational biophysics
Picture of the three crystal systems examined in this study. These systems contain (from left to right) 27, 24 and 36 double-stranded DNA respectively. Pablo Dans Puiggròs, IRB Barcelona.
Scientific
Scientists achieve the first stable simulations of DNA crystals
Scheme of the intracellular processing of the 2shRNAs by the activity of Dicer enzyme, producing two independent fragments of shRNA, one against each target (M Terrazas, IRB Barcelona)
Innovation
Advances made to combat cancer relapse
European Research Council (ERC)
Media mentions
ERC has awarded five grants to research projects in Barcelona
Modesto Orozco, head of the Molecular Modelling and Bioinformatics Lab at IRB Barcelona
Media mentions
Modesto Orozco receives an ERC Proof of Concept
Innovation
An ERC Proof of Concept grant to fight drug resistance in breast cancer