To understand protein function and mechanism of action, it is essential to study protein complex assembly and structure, as well as the interactions between different molecules.
It is important to understand which conformational changes are produced upon small-molecule binding or which molecules can bind target proteins better than their own natural ligands, as per improving biotherapeutic design. IRB Barcelona has skilled scientific staff in techniques from bioinformatics simulations to biophysical or spectroscopic analysis and can apply them to evaluate the structural changes behind an observed experimental observation. Furthermore, the institute can bring together complementary techniques as per addressing complex questions and projects.
Some of the available techniques:
- Molecular dynamics simulation
- Molecular docking
- Isothermal titration calorimetry (ITC)
- Nuclear magnetic resonance (NMR)
- X-ray crystallography
- Fluorescence polarisation
- Static and dynamic light scatterings (SLS & DLS)
- Thermal-shift assay
- Mass-spectrometry
- Flow-cytometry
- ...
Contact
