Quantitative dynamics of aging and premalignancy

14 nov. 22

- 16 nov. 22

Since the dawn of civilization, humans have been puzzled about the effect of time on our physiology and decay. Only in the last decades notable advances have been made as we begin to unravel the causes and mechanisms of aging. On one hand, it is clear that epigenetic alterations accumulate with age, leading to disrupted cell function and tissue pathology. Exciting advances are now exploring whether epigenetic reprogramming can be sufficient to revert the phenotypic traits of aged organs. On the other hand, provoking new studies are increasingly supporting the mutational hypothesis of aging. It is evident that some stem cell clones acquire somatic mutations that endow them with a self-renewal advantage, leading to their expansion and tissue-takeover in old age. Various researchers are beginning to explore how clonal mosaicism can contribute to organismal aging across scales. At the crossroads of these hypotheses lies the blood and immune system, which pervades most organs and contributes to various critical mechanisms of aging and tumor control.

Presentation

Conference description

This conference will provide an interdisciplinary forum for researchers interested in aging, somatic mosaicism, epigenetics, plasticity, stem cells and immunity. We will give specific focus to methodological and quantitative advances from the fields of genomics and single-cell biology, which have led to a revolution in the way we are understanding aging and tumor evolution. A true synthesis of all these fields will be required to identify the best avenues to delay the onset of age-related diseases in the elderly.

Conference organizers

Dr. Alejo Rodriguez-Fraticelli
IRB Barcelona
Barcelona, Spain

Dr. Salvador Aznar Benitah
IRB Barcelona/ ICREA
Barcelona, Spain

Dr. John E. Dick
University Health Network
Toronto, ON, Canada

Organized in colaboration with:

logo fundación bbva

There is no registration fee for this conference, but the number of participants is limited, with a number of seats saved for IRB Barcelona alumni. Previous registration is required.

Participants are invited to submit abstracts, a number of which will be selected for short talk and poster presentations. Abstracts should include a title, authors, affiliations, summary (max 250 words) and references

Dates importants

REGISTRATION DEADLINE: 10 OCTOBER, 2022

Poster Quantitative dynamics of aging and premalignancy (1.2 MB)

Programme Quantitative dynamics of aging and premalignancy (516.11 KB)

Programme

Monday, 14 November

8.30 Registration

9.00 Welcome by Dr. Raúl Méndez (IRB Barcelona, Vice Director) and organizers (Dr. Alejo Rodriguez-Fraticelli, Dr. John E. Dick, Dr. Salvador Aznar-Benitah)

Session 1: Deregulated stem cell mechanisms in aging and cancer

Chair: Dr. Salvador Aznar-Benitah

9.15 What Makes a Stem Cell a Stem Cell and How Does it Go Bad in AML

Dr. John E. Dick, University Health Network (Toronto, ON, Canada)

9.50 Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

Dr. Lars Velten, CRG (Barcelona, Spain)

10.25 Short talk 1: Understanding the role of PHF19 in acute Myeloid leukemias (AMLs): from patients data analysis to cell in-vitro characterization

Gianni Paolo Gamarra Figueroa, CRG (Barcelona, Spain)

10.40-11.15 Coffee break and poster session

11.15 Somatic evolution in normal and neoplastic hematopoiesis through the lens of single-cell multi-omics

Dr. Dan A. Landau, New York Genome Center (New York, NY, USA)

11.50 Clonal determinants of stem cell heterogeneity

Dr. Alejo Rodriguez-Fraticelli, IRB Barcelona (Barcelona, Spain)

12:25 Principles of regeneration captured by imaging the skin of live mice

Dr. Valentina Greco, Yale University School of Medicine (New Haven, CT, USA)

13.00 Short talk 2: Stromal niche instructs early tumour formation

Dr. Maria P. Alcolea, Wellcome – MRC Cambridge Stem Cell Institute (Cambridge, UK)

13.15-15.00 Lunch and poster session

Session 2: Dynamics of aging

Chair: Dr. Alejo Rodriguez-Fraticelli

15.00 A map of circulating HSCs in age and disease

Dr. Liran Shlush, Weizmann Institute of Science (Rehovot, Israel)

15.35 Systemic regulation of physiology by circadian clocks in youth and during aging

Dr. Salvador Aznar-Benitah, IRB Barcelona/ ICREA (Barcelona, Spain)

16.10 Short talk 3: Protective role of cellular heterogeneity preserving the plasticity and complexity of transcriptional networks during ageing

Dr. Celia P. Martinez-Jimenez, Helmholtz Zentrum Munchen (München, Germany)

16.25-16.55 Coffee break and poster session

16.55 New approaches to enhance regeneration of aged muscles: a focus on senescent cells

Dr. Pura Muñoz-Cánoves, UPF (Barcelona, Spain)

17.30 Intestinal Stem Cell Aging: local and systemic effects

Dr. Heinrich Jasper, Genentech Inc. (South San Francisco, CA, USA)

18.00 Short talk 4: Genome segmentation by UV light DNA damage repair dynamics

Hanna Kranas, IRB Barcelona (Barcelona, Spain)

18.15 End of session

Tuesday, 15 November

Session 3: Clonal evolution in aging and cancer

Chair: Dr. Alejo Rodriguez-Fraticelli

9.00 Somatic mutations in tumors and normal tissues

Dr. Núria López-Bigas, IRB Barcelona/ ICREA (Barcelona, Spain)

9.35 Somatic mutation in normal tissues

Dr. Iñigo Martincorena, Wellcome Sanger Institute (Cambridge, UK)

10.10 Short talk 5: Genome-wide analyses of 200,453 individuals yields new insights into the causes and consequences of clonal hematopoiesis

Dr. Pedro M. Quiros, Instituto de Investigación Sanitaria del Principado de Asturias (Oviedo, Asturias)

10.25 Short talk 6: Somatic LMNA mutation and expression of progerin in early vascular aging of chronic kidney disease

Dr. Gwladys Revêchon, Karolinska Institutet (Huddinge, Sweden)

10.40-11.10 Coffee break and poster session

11.10 Injury-induced cellular reprogramming as a driver of preneoplastic transformation and tumour initiation in epithelial tissues

Dr. Benjamin D. Simons, Wellcome Trust-Cancer Research UK Gurdon Institute (Cambridge, UK)

11.45 Haematopoiesis across the human lifespan at single cell resolution

Dr. Elisa Laurenti, Wellcome-MRC Cambridge Stem Cell Institute (Cambridge, UK)

12.20 Genetic determinants of clonal expansion rate in pre-malignant HSCs

Dr. Siddartha Jaiswal, Stanford Medicine (Stanford, CA, USA)

12.55 Short talk 7: Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis

Dr. Santiago Demajo, IRB Barcelona (Barcelona, Spain)

13.10-15.00 Lunch and poster session

Session 4: Immune processes

Chair: Dr. Salvador Aznar-Benitah

15.00 Circadian biology in the bone marrow

Dr. Andrés Hidalgo, CNIC (Madrid, Spain)

15.35 Rejuvenated blood stem cells extend lifespan of aged immunocompromised mice

Dr. Maria Carolina Florian, IDIBELL (Barcelona, Spain)

16.10 Short talk 8: Clonal haematopoiesis shapes the immune system: the case of the preleukemic neutrophil

Dr. Hector Huerga, The Francis Crick Institute (London, UK)

16.25-17.00 Coffee break and poster session

17.00 Short talk 9: Age-associated T cells drive myelopoiesis skewing in old mice

Dr. Enrique Gabandé-Rodríguez, CBM- CSIC (Madrid, Spain)

17.10 Short talk 10: Local IL-17 orchestrates skin aging

Dr. Guiomar Solanas, IRB Barcelona (Barcelona, Spain)

17.30 End of session

20.30 Speakers dinner (Restaurant Can Pineda) (Sant Joan de Malta, 55)

Wednesday, 16 November

Session 5: Cell plasticity, aging and cancer

Chair: Dr. Salvador Aznar-Benitah

9.00 Formaldehyde induced endogenous DNA damage disrupts blood regeneration, nutritional homeostasis and promotes ageing

Dr. Ketan J. Patel, MRC Weatherall Institute of Molecular Medicine (Oxford, UK)

9.35 Understanding and controlling cellular plasticity

Dr. Manuel Serrano, IRB Barcelona/ ICREA (Barcelona, Spain)

10.10 Short talk 11: Organelle age landscape in skin

Dr. Agustin Sola Carvajal, Karolinska Institute (Stockholm, Sweden)

10.25-11.00 Coffee break and poster session

11.00 Neoplastic co-option of epigenetic plasticity and epithelial-immune interactions

Dr. Direna Alonso-Curbelo, IRB Barcelona (Barcelona, Spain)

11.35 Regulation of stem cell fate and dynamics by niche derived factors and forces

Dr. Sara Wickström, Faculty of Medicine and Helsinki Institute of Life Science (Helsinki, Finland)

12.10 Nutrient dependencies of metastasis formation

13.00 Concluding remarks and end of conference

Venue

The BARCELONA BIOMED CONFERENCE Quantitative dynamics of aging and premalignancy will be placed at the Casa Convalescència in the heart of Barcelona. Talks will take place in the Aula Magna.

Casa Convalescència
C/ Sant Antoni Maria Claret, 171
08041 Barcelona

Tel +34 934 335 000
www.uab-casaconvalescencia.org

How to reach the Casa Convalescència:

Underground
Yellow line (L4) - GUINARDÓ – HOSPITAL DE SANT PAU station
Blue line (L5) - SANT PAU – DOS DE MAIG station

By bus
Lines: 15, 19, 20, 45, 47, 50, 51, 92 and 192.

For the GPS
Introduce the following coordinates:
Latitude: 41.413702 (41° 24' 49.33'' N)
Longitude: 2.177482 (2° 10' 38.94'' E)

From the airport

* Train + Underground. At the RENFE station, take the train to Sants-Estació. Once there take the Underground's blue line (L5) till SANT PAU – DOS DE MAIG station.
* Bus + Underground. Outside the airport terminal, take the AEROBUS to Plaça Catalunya. Walk one corner till Plaça Urquinaona and take the Underground's yellow line (L4) to GUINARDÓ – HOSPITAL DE SANT PAU station.

Barcelona Metropolitan Transport webiste (with metro and bus maps)

Accomodation

Speakers will be lodged at the Hotel Catalonia Atenas
Av. Meridiana, 151
08026, Barcelona
Telephone: +34 93 232 20 11
e-mail: catalonia@cataloniahotels.com
www.hoteles-catalonia.com

Other hotels
A list of additional hotels within walking distance of the Casa Convalescència can be found at: https://www.barcelona-tourist-guide.com/en/hotels/hotelmaps/eixample-right-barcelona-hotel.html
(The Casa Convalescència is located near the violet point 27/3 star). Rates will vary depending on choice of hotel and season. Please check with the hotel of your choice directly for the best offer.

Residences
Another possibility is the Lesseps Residence Hall, and is available for short-term stays.

Lesseps Residence Hall
Plaza Lesseps, 12 08023 Barcelona
View on map
Telephone: +34 933 941 600
e-mail: lesseps@resa.es
www.resa.es/en/city/barcelona

Participants registered for events in the Barcelona BioMed series should contact the hotels and residences directly to arrange bookings and payment.