Published in Science
An international team has published a key discovery about Mitofusin 2 in the journal Science. This mitochondrial protein, which exists in different forms, acts as both a connector and regulator between mitochondria and the endoplasmic reticulum, crucial for cellular operation. The finding sheds light on the underlying mechanisms of conditions like Charcot-Marie-Tooth IIA neuropathy and metabolic disorders, thereby offering new therapeutic avenues.
Co-directed by Dr. Antonio Zorzano at IRB Barcelona, Dr. Luca Scorrano at VIMM and the University of Padua, and Dr. Deborah Naón, member of both teams, the study reveals "variants" of Mitofusin 2, named ERMIT2 and ERMIN2, produced through alternative splicing. These play vital roles in organelle communication, affecting lipid metabolism and overall cellular health. With potential implications for treating metabolic and neuromuscular diseases, this research emphasises the importance of organelle interaction in cellular functionality and disease, and paves the way for innovative treatments.
For more information:
https://www.irbbarcelona.org/en/news/scientific/scientists-unveil-mechanism-behind-intracellular-connection-mitofusin-2-lock-and
