Cristina Mayor-Ruiz

Unit:

Mechanisms of Disease

Position:

Junior Group Leader

Office:

EM01B24

Telephone:

+34 93 40 24562

Email:

cristina.mayor-ruiz@irbbarcelona.org

Research Group

Targeted protein degradation and drug discovery

Mecanismos de las Enfermedades

TRIP Clinics lab - Chemical Modulation of Proteolysis in Sarcoma Contexts

Mecanismos de las Enfermedades

Cristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of Óscar Fernández-Capetillo, exploring mechanisms of resistance to genotoxic and targeted anticancer therapies. In 2018, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships, where her research interests focused on different aspects of chemical biology and targeted protein degradation.

Selected group publications

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders

Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C

Angewandte Chemie (International Ed. Print)

(12 )

e202316730 -

e202316730

(2024)

Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation

Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C

Chembiochem

(10 )

e202300163 -

e202300163

(2023)