Speaker: Prof Simon Newstead - Professor Molecular Membrane Biology - Wellcome Trust Investigator - Biochemistry Tutor Christ Church - Department of Biochemistry - University of Oxford
Presentation
Organizer: IRB Barcelona
Date: Friday, 19 November 2021, 12.00
Place: Felix Serratosa Hall
Host: Manuel Palacín, PhD - IRB Barcelona
Abstract:
Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs are the second-largest family of membrane proteins in the human genome and can be seen as cellular gatekeepers, controlling the flow and balance of nutrients in the body. The past 10 years we have seen an explosion in our understanding of the structural and biochemical basis for SLC function, which combined with previous physiological studies has revolutionised SLC biology. Recently our group reported the structures for SLC transporters involved in peptide and folic acid uptake in the human body, revealing key mechanistic insights into proton coupled nutrient acquisition (www.newsteadgroup.org). Importantly, many SLC proteins function as important routes for drug delivery in cancer and oral absorption. In this seminar I will discuss our recent findings and discuss their implications for advancing SLC biology and developing more effective anticancer, antiviral and antibiotic drugs.
Important: For attendees outside the PCB community you must register at least 24hours before the seminar.