Presentation
Organizer: IRB BioMed Seminars
Date: Monday 13 June, 12:00h
Place: Auditorium, PCB
Speaker: Jose Ordovas-Montanes, PhD - GL - Research Faculty - Division of Gastroenterology - Boston Children's Hospital - Assistant Professor of Pediatrics - Harvard Medical School - Robertson Investigator - New York Stem Cell Foundation - Principal Faculty - Harvard Stem Cell Institute
Title: "Single-cell biology of barrier tissues"
Host: Alejo Rodriguez-Fraticelli, PhD
Abstract:
For a barrier tissue to effectively learn from previous immunological experiences, it can sense, adapt, and store this information in essential or resident cell types. The foundational architecture of barriers includes essential stromal and stem-cell derived epithelial cell subsets that collectively perform key tissue functions. These cell subsets are critical for responding to, and learning from, environmental challenges, together with the support of resident immune cells. However, the ability of barrier tissues such as the skin, gut or airway to efficiently adapt can become dysregulated during acute infection with viruses (SARS-CoV-2) or chronic disease states (inflammatory bowel disease). Identifying the essential cell types, states and circuits of communication which predict and sustain disease in humans is vital to effectively treating these conditions. Our work across barrier tissues suggests that deriving insights from single-cell measurements can identify predictive determinants of organismal health and disease.
IRB BioMed Seminars
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.