Regina Freier

Unit:

Structural & Computational Biology

Position:

Alumni - Postdoctoral Fellow

Office:

EM01B41-42

Telephone:

+34 93 40 37188

Email:

regina.freier@irbbarcelona.org

Left IRB Barcelona in May 2018

Research Group

Structural Characterization of Macromolecular Assemblies

Mechanisms of Disease

Selected group publications

TGF-β and RAS jointly unmask primed enhancers to drive metastasis

Lee, Jun Ho; Sánchez-Rivera, Francisco J.; He, Lan; Basnet, Harihar; Chen, Fei Xavier; Spina, Elena; Li, Liangji; Torner, Carles; Chan, Jason E.; Yarlagadda, Dig Vijay Kumar; Park, Jin Suk; Sussman, Carleigh; Rudin, Charles M.; Lowe, Scott W.; Tammela, Tuomas; Macias, Maria J.; Koche, Richard P.; Massagué, Joan

Cell

187

(22 )

6182 -

6199.e29

(2024)

AI is a viable alternative to high throughput screening: a 318-target study

Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O'Sullivan, AM; Davtyan, A; Samudio, B; Thomas, B; Worley, B; Butler, B; Laggner, C; Thayer, D; Moharreri, E; Friedland, G; Truong, H; van den Bedem, H; Ng, HL; Stafford, K; Sarangapani, K; Giesler, K; Ngo, L; Mysinger, M; Ahmed, M; Anthis, NJ; Henriksen, N; Gniewek, P;...

Scientific Reports

(1 )

7526 -

(2024)

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

Pous, J; Baginski, B; Martin-Malpartida, P; González, L; Scarpa, M; Aragon, E; Ruiz, L; Mees, RA; Iglesias-Fernández, J; Orozco, M; Nebreda, AR; Macias, MJ

Nature Communications

(1 )

7920 -

(2023)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications

(1 )

3318 -

(2023)

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1

Pluta, R; Aragon, E; Prescott, NA; Ruiz, L; Mees, RA; Baginski, B; Flood, JR; Martin-Malpartida, P; Massague, J; David, Y; Macias, MJ

Nature Communications

(1 )

7279 -

(2022)