Isabelle Brun-Heath

Unit:

Mechanisms of Disease

Position:

Lab Director

Office:

CL01C61-62

Telephone:

+34 93 40 20180

Email:

isabelle.heath@irbbarcelona.org

Research Group

Molecular Modelling and Bioinformatics

Mechanisms of Disease

Experimental Bioinformatics Laboratory (EBL)Director

Selected group publications

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

Nucleic Acids Research

(10 )

4713 -

4725

(2023)

López-Güell, K; Battistini, F; Orozco, M

Nucleic Acids Research

(6 )

2633 -

2640

(2023)

pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs

Serrano-Chacon, I; Mir, B; Cupellini, L; Colizzi, F; Orozco, M; Escaja, N; Gonzalez, C

Journal Of The American Chemical Society

145

(6 )

3696 -

3705

(2023)

Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells

Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C

Nucleic Acids Research

(6 )

3375 -

3389

(2024)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications

(1 )

3318 -

(2023)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

Nucleic Acids Research

(10 )

4713 -

4725

(2023)

López-Güell, K; Battistini, F; Orozco, M

Nucleic Acids Research

(6 )

2633 -

2640

(2023)

pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs

Serrano-Chacon, I; Mir, B; Cupellini, L; Colizzi, F; Orozco, M; Escaja, N; Gonzalez, C

Journal Of The American Chemical Society

145

(6 )

3696 -

3705

(2023)

Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells

Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C

Nucleic Acids Research

(6 )

3375 -

3389

(2024)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

Nature Communications

(1 )

3318 -

(2023)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

Nucleic Acids Research

(10 )

4713 -

4725

(2023)

Dr. Isabelle Brun-Heath