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Laboratory of Molecular Biophysics News

In red, the domain of the androgen receptor protein where drugs to treat prostate cancer bind. In blue and black, parts of the protein where it might be feasible to direct new drugs (Author: Xavier Salvatella, IRB Barcelona)
Innovation
2M€ for studying protein motions and their implications for the treatment of prostate cancer
Innovation
Rare and orphan but not abandoned by science
irbbarcelona
Media mentions
From Protein Dance Positions to Protein-Drug Pas de Deux
Xavier Salvatella leads the Laboratory of Molecular Biophysics (Battista/Minocri, IRB Barcelona)
Scientific
The transmission of information via proteins could revolutionize drug discovery
Graphic explaining the consequences of the loss of function of RARRES3 for breast cancer lung metastasis (Author: Gomis Lab, IRB)
Scientific
Researchers identify a new suppressor of breast metastasis to the lung
MareNostrum supercomputer facility at BSC (Image rights: BSC)
Institutional
Three Severo Ochoa Centres of Excellence join efforts in computational biology
irbbarcelona
Media mentions
Salvatella: "IRB is a bit like Janelia Farm on the Barcelona's Diagonal Avenue"
Diagram of the protein unfolding in presence of urea. Author: M Candotti © IRB Barcelona
Scientific
Proteins in detail
Media mentions
Molecular dynamics may change the research on future drugs
Media mentions
Protein dynamics: Whispering within
irbbarcelona
Scientific
The dancing amino acids of ubiquitin
Proteins with disulphide bridges form more stable and less toxic fibers that those that do not have these bridges.
Scientific
The fight against the toxic aggregation of proteins according to Darwin
Media mentions
Elusive proteins
Media mentions
Kennedy's Disease, a mystery, but not for much longer
Institutional
IRB Barcelona and the BSC renew and expand their joint research programme in order to further computational biology
Media mentions
Tracking the early stages of Alzheimer's disease
Picture of the awarded researchers with the authorities during the event.
Institutional
IRB Barcelona coordinates a study on rare diseases
Although these two types of fibers are formed by the same protein, the ones above are toxic and the ones below are not.
Scientific
The toxicity of amyloid fibers depends on their structure
Media mentions
Biology is the new physics
irbbarcelona
Media mentions
Spanish scientists develop a new method to "photograph" proteins and to design new drugs
In blue, prediction of the structure of denaturalized ubiquitin protein by previous computational models. In red, refined structures with the ERIDU model. These structures coincide with experimental data. © Salvatella lab. IRB Barcelona
Scientific
New method to study key targets in Alzheimer's disease and prostate cancer