Selected Publications | 2023 Annual Report

Splice variants of Mitofusin 2 shape the endoplasmic reticulum ant tether it to mitochondria.

Naon, D; Hernandez-Alvarez, MI; Shinjo, S; Wieczor, M.; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacin, M; Aparicio, P; Castellanos, J; Lores, L; Sebastian, D; Fernandez-Veledo, S; Vendrel, J; Joven, J; Orozco, M; Zorzano, A*; Scorrano, L.*
Science, 380 (6651): eadh9351 (2023)
DOI: 10.1126/science.adh9351

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.

Burdziak C*, Alonso-Curbelo D*, Walle T, Reyes J, Barriga FM, Haviv D, Xie Y, Zhao Z, Zhao CJ, Chen HA, Chaudhary O, Masilionis I, Choo ZN, Gao V, Luan W, Wuest A, Ho YJ, Wei Y, Quail DF, Koche R, Mazutis L, Chaligné R, Nawy T, Lowe SW, Pe'er D.
Science, 380: eadd5327 (2023)
DOI: 10.1126/science.add5327

Cellular senescence is immunogenic and promotes anti-tumor immunity.

Marin I; Boix O; Garcia-Garijo A; Sirois I; Caballe A; Zarzuela E; Ruano I; Stephan-Otto Attolini C; Prats N; Lopez-Dominguez JA; Kovatcheva M; Garralda E; Munoz J; Caron E; Abad M; Gros A; Pietrocola F; Serrano M.
Cancer Discovery, 13, 410-431 (2023)
DOI: 10.1158/2159-8290.CD-22-0523

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity.

Chen HA; Ho YJ; Mezzadra R; Adrover JM; Smolkin R; Zhu C; Woess K; Bernstein N; Schmitt G; Fong L; Luan W; Wuest A; Tian S; Li X; Broderick C; Hendrickson RC; Egeblad M; Chen Z; Alonso-Curbelo D*; Lowe SW*
Cancer Discovery, 13, 432-453 (2023)
DOI: 10.1158/2159-8290.CD-22-0528

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair.

Kovatcheva M, Melendez E, Chondronasiou D, Pietrocola F, Bernad R, Caballe A, Junza A, Capellades J, Holguín-HA, Prats N, Durand S, Rovira M, Yanes O, Stephan-Otto Attolini C, Kroemer G, Serrano M
Nature Metabolism, 5, 911–1930 (2023)
DOI: 10.1038/s42255-023-00916-6

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype.

Maus, M; López-Polo, V; Mateo, L; Lafarga, M; Aguilera, M; De Lama, E; Meyer, K; Sola, A; Lopez-Martinez, C; López-Alonso, I; Guasch-Piqueras, M; Hernandez-Gonzalez, F; Chaib, S; Rovira, M; Sanchez, M; Faner, R; Agusti, A; Diéguez-Hurtado, R; Ortega, S; Manonelles, A; Engelhardt, S; Monteiro, F; Attolini, CSO; Prats, N; Albaiceta, G; Cruzado, JM; Serrano, M
Nature Metabolism 5, 2111–2130 (2023)
DOI: 10.1038/s42255-023-00928-2

Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy.

Redondo-Munoz, M; Rodriguez-Baena, FJ; Aldaz, P; Caballe-Mestres, A; Moncho-Amor, V; Otaegi-Ugartemendia, M; Carrasco-Garcia, E; Olias-Arjona, A; Lasheras-Otero, I; Santamaria, E; Bocanegra, A; Chocarro, L; Grier, A; Dzieciatkowska, MM; Bigas, C; Martin, J; Urdiroz-Urricelqui, U; Marzo, F; Santamaria, E; Kochan, G; Escors, D; Larrayoz, IM; Heyn, H; D'Alessandro, A; Attolini, CSO; Matheu, A; Wellbrock, C; Benitah, SA*; Sanchez-Laorden, B*; Arozarena, I*
Nature Metabolism. 5, 1544 (2023)
DOI: 10.1038/s42255-023-00861-4

Targeting lymphoid-derived IL-17 signaling to delay skin aging.

Sola, P; Mereu, E; Bonjoch, J; Casado-Pelaez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Aznar-Benitah, S.
Nature Aging, 3, 688–704 (2023).
DOI: 10.1038/s43587-023-00431-z

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing.

Sanfeliu-Cerdán N, Català-Castro F, Mateos B, Garcia-Cabau C, Ribera M, Ruider I, Porta-de-la-Riva M, Canals-Calderón A, Wieser S, Salvatella X*, Krieg M*
Nature Cell Biology, 25, 1590–1599 (2023) (2023)
DOI: 10.1038/s41556-023-01247-0

MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis.

Llorente A, Blasco MT, Espuny I, Guiu M, Ballaré C, Blanco E, Caballé A, Bellmunt A, Salvador F, Morales A, Nuñez M, Loren G, Imbastari F, Fidalgo M, Figueras-Puig C, Gibler P, Graupera M, Monteiro F, Riera A, Holen I, Avgustinova A, Di Croce L, Gomis RR
Nature Cell Biology, 25, 1833–1847 (2023)
DOI: 10.1038/s41556-023-01281-y

Rational optimization of a transcription factor activation domain inhibitor.

Bsu S#, Martínez-Cristóbal P#, Pesarrodona M, Frigolé-Vivas M, Lewis M, Szulc E, Bañuelos CA, Sánchez-Zarzalejo C, Bielskutė S, Zhu J, Pombo-García K, Garcia-Cabau C, Zodi L, Dockx H, Smak J, Kaur H, Batlle C, Mateos B, Biesaga M, Escobedo A, Bardia L, Verdaguer X, Ruffoni A, Mawji NR, Wang J, Obst JK, Tam T, Brun-Heath I, Ventura S, Meierhofer D, García J, Robustelli P, Stracker TH, Sadar MD*, Riera A*, Hnisz D*, Salvatella X*
Nature Structural & Molecular Biology, 30, 958–1969 (2023)
DOI: 10.1038/s41594-023-01159-5

Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein.

Machón C; Ruiz-Masó JA; Amodio J; Boer DR; Bordanaba-Ruiseco L; Bury K; Konieczny I; Del Solar G; Coll M
Nucleic Acids Research, 51, 1458-1472 (2023)
DOI: 10.1093/nar/gkac1271

Correlated motions in DNA: beyond base-pair step models of DNA flexibility.

López-Güell K; Battistini F; Orozco M
Nucleic Acids Research, 51, 6 , 2633-2640 (2023)
DOI: 10.1093/nar/gkad136

Controlled Sulfur-Based Engineering Confers Mouldability to Phosphorothioate Antisense Oligonucleotides.

Genna V, Iglesias J, (…), Villalobos A and Orozco M
Nucleic Acids Research, 51, 4713-4725 (2023)
DOI: 10.1093/nar/gkad309

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation.

Irazoki A; Gordaliza-Alaguero I; Frank E; Giakoumakis NN; Seco J; Palacín M; Gumà A; Sylow L; Sebastián D; Zorzano A
Nature Communications, 14, 108 (2023)
DOI: 10.1038/s41467-022-35732-1

Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG.

Ali A; Vineethakumari C; Lacasa C; Lüders J
Nature Communications, 14, 289 (2023)
DOI: 10.1038/s41467-023-35955-w

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis.

Domingo-Muelas A; Duart-Abadia P; Morante-Redolat JM; Jordán-Pla A; Belenguer G; Fabra-Beser J; Paniagua-Herranz L; Pérez-Villalba A; Álvarez-Varela A; Barriga FM; Gil-Sanz C; Ortega F; Batlle E*; Fariñas I*
Nature Communications, 14, 373 (2023)
DOI: 10.1038/s41467-023-36054-6

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

González L, Díaz L, Pous J, Baginski B, Duran-Corbera A, Scarpa M, Brun-Heath I, Igea A, Martin-Malpartida P, Ruiz L, Pallara C, Esguerra M, Colizzi F, Mayor-Ruiz C, Biondi RM, Soliva R, Macias MJ, Orozco M, Nebreda AR
Nature Communications, 14, 3318 (2023)
DOI: 10.1038/s41467-023-39051-x

Origin of fungal hybrids with pathogenic potential from warm seawater environments.

del Olmo, V; Mixao, V; Fotedar, R; Saus, E; Al Malki, A; Ksiezopolska, E; Nunez-Rodriguez, JC; Boekhout, T; Gabaldón, T
Nature Communications. 14 (1): 6919 (2023)
DOI: 0.1038/s41467-023-42679-4