Finding the needle in the haystack – target identification of anti-cancer small molecules [IRB Research Nodes Seminar]

Host: Manuel Serrano

Node: Preclinical Models of Cancer / Preclinical Models of Disease  

Date: Wednesday 15 June 2022, 12.00h

Abstract

Identification of the mechanism of action of small molecules is one of the main roadblocks in drug development. In the last years, I have developed genetic and chemoproteomic tools to unequivocally identify the target of small molecules with anti-cancer activity. These tools have led to the discovery of the target of a small molecule currently in clinical trials for the treatment of Ewing sarcoma.