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Research

At the forefront of biomedicine

Natalia Castillo

Unit:
Position:
PhD Student
Office:
EM01B24
Telephone:
+34 93 40 37123
Research Group

Selected group publications

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C
Angewandte Chemie (International Ed. Print)
63
(12 )
e202316730 -
e202316730
(2024)
Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation
Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C
Chembiochem
24
(10 )
e202300163 -
e202300163
(2023)
Molecular glue degraders: From serendipity to hunting and design
Nieto-Barrado L; Domostegui A; Mayor-Ruiz C
In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.
Chapter 6
177 -
204
(2022)
Chasing molecular glue degraders: screening approaches
Domostegui, A; Nieto-Barrado, L; Perez-Lopez, C; Mayor-Ruiz, C
Chemical Society Reviews
51
(13 )
5498 -
5517
(2022)
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
Scholes, NS; Mayor-Ruiz, C; Winter, GE
Cell Chemical Biology
28
(7 )
1048 -
1060
(2021)