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Research

At the forefront of biomedicine

Dr. Manuel Serrano

Unit:
Position:
Affiliated Group Leader
Office:
EM01C42-44
Research Group

Manuel Serrano obtained his PhD in 1991 in Madrid, Spain.  In 1993, as a postdoctoral researcher in the laboratory of David Beach at Cold Spring Harbor Lab, NY, USA, he reported the discovery of the gene p16, a key anti-cancer gene and inducer of cellular senescence. From 1997 to 2022, Serrano developed his career in Spain, initially in Madrid and since 2017 in Barcelona. His laboratory has made important contributions to the fields of cellular senescence and cellular reprogramming. In 2023, Serrano moved to Altos Labs in Cambridge, UK, where he continues investigating senescence and reprogramming with the aim of understanding and treating aging and its associated diseases.

Current researcher's video

Selected group publications

Deciphering the roadmap of in vivo reprogramming toward pluripotency
Chondronasiou, D; de Villarreal, JM; Melendez, E; Lynch, CJ; del Pozo, N; Kovatcheva, M; Aguilera, M; Prats, N; Real, FX; Serrano, M
Stem Cell Reports
17
(11 )
2501 -
2517
(2022)
The lysosomal proteome of senescent cells contributes to the senescence secretome
Rovira, M; Sereda, R; Pladevall-Morera, D; Ramponi, V; Marin, I; Maus, M; Madrigal-Matute, J; Díaz, A; García, F; Muñoz, J; Cuervo, AM; Serrano, M
Aging Cell
21
(10 )
e13707 -
e13707
(2022)
Natural killer cells act as an extrinsic barrier for in vivo reprogramming
Melendez, E; Chondronasiou, D; Mosteiro, L; de Villarreal, JM; Fernandez-Alfara, M; Lynch, CJ; Grimm, D; Real, FX; Alcami, J; Climent, N; Pietrocola, F; Serrano, M
Development
149
(8 )
dev200361 -
(2022)
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Chondronasiou, D; Gill, D; Mosteiro, L; Urdinguio, RG; Berenguer, A; Aguilera, M; Durand, S; Aprahamian, F; Nirmalathasan, N; Abad, M; Martin-Herranz, DE; Otto-Attolini, CS; Prats, N; Kroemer, G; Fraga, MF; Reik, W; Serrano, M
Aging Cell
21
(3 )
e13578 -
(2022)
Dissection of two routes to naive pluripotency using different kinase inhibitors
Martinez-Val, A; Lynch, CJ; Calvo, I; Ximenez-Embun, P; Garcia, F; Zarzuela, E; Serrano, M; Munoz, J
Nature Communications
12
(1 )
1863 -
(2021)