Lian Porta

Unit:

Mechanisms of Disease

Position:

Visiting Student

Office:

EM01B24

Telephone:

+34 93 40 37123

Email:

lian.porta@irbbarcelona.org

Research Group

Targeted protein degradation and drug discovery

Mechanisms of Disease

Selected group publications

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders

Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C

Angewandte Chemie (International Ed. Print)

(12 )

e202316730 -

e202316730

(2024)

Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation

Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C

Chembiochem

(10 )

e202300163 -

e202300163

(2023)

Molecular glue degraders: From serendipity to hunting and design

Nieto-Barrado L; Domostegui A; Mayor-Ruiz C

In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.

Chapter 6

177 -

204

(2022)

Chasing molecular glue degraders: screening approaches

Domostegui, A; Nieto-Barrado, L; Perez-Lopez, C; Mayor-Ruiz, C

Chemical Society Reviews

(13 )

5498 -

5517

(2022)

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

Scholes, NS; Mayor-Ruiz, C; Winter, GE

Cell Chemical Biology

(7 )

1048 -

1060

(2021)