Speaker: Prof. M. Eugenio Vázquez
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Química Orgánica. Universidade de Santiago de Compostela. Spain
Presentation
Host: Dr. María J. Macías, Group Leader - Structural Characterization of Macromolecular Assemblies - IRB Barcelona
Node: Chemical & Structural Biology
Date: Wednesday 25 October 2023, 12.00h
Place: Auditorium Room
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.
Abstract
The development of artificial metalloenzymes (ArMs) that catalyze novel transformations and expand the repertoire of biocompatible reactions available in living cells is a major research challenge at the intersection of catalysis, protein engineering, and chemical biology. Catalytic metallopeptides, halfway between conventional transition metal catalysts and protein-based ArMs, may hold the key to efficient catalysis in biological settings. In this context, we will describe the latest advances in our group in the development of catalytic metallopeptides using rational methods and combinatorial chemistry.