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Microtubule organization in cell proliferation and differentiation News

3D structure of the human γ-tubulin ring complex.
Scientific
New discovery on how cells build their internal skeleton
Scientific
The ch-TOG protein is essential for building and maintaining the cell skeleton
Scientific
Centriole instability might contribute to some cases of microcephaly
Scientific
Key element identified in stem cell division 
and embryo development
3D structure of the human γ-tubulin ring complex.
Scientific
Scientists from IRB Barcelona and CNIO assemble the γ-tubulin ring complex in vitro for the first time
Microscopy image of a human cell showing VPS13B protein (red) at the Golgi (green), next to the nucleus (blue). Image: Microtubule Organization lab.
Institutional
La Marató awards funding to a rare diseases project at IRB Barcelona
Media mentions
NCAM2 protein is crucial for the development of structures involved in cognitive learning such as the cerebral cortex and the hippocampus.
Biennal Ciutat i Ciència
Outreach
IRB Barcelona to participate in the first Biennal Ciutat i Ciència event
The picture shows cultured neurons prepared from brains of control mice (left) and mice in which the Nek7 gene is knocked out. The dendrites are overall shorter and less branched in NEK7 knockout neurons.
Media mentions
A protein that regulates memory-related neuron formation is been identified
The picture shows a cultured neuron stained with antibodies that label microtubules. NEK7 promotes the stability of the dendritic microtubules, which is important for proper dendrite growth and branching (F Freixo, IRB Barcelona)
Scientific
New regulator of neuron formation identified
Travis Stracker, Renata Basto and Jens Lüders, organizers of the BioMed Conference
Institutional
Connections between the cell cycle, centrosomes and cilia are gaining attention in biomedicine
Institutional
Jens Lüders: “Curiosity should fuel research”
Media mentions
Researchers discover a mechanism that allows neurons to form new extensions
Microscopy image of a culture mouse neuron showing the microtubule network in green and red depending on chemical modifications. The axon, in bright green, is the neuronal extension that has the greatest number of modified microtubules (Author: Carlos Sán
Scientific
Researchers discover the machinery that neurons use to form and maintain their neuronal extensions
CEP63 depletion increases stem cell death in the developing mouse brain. The image on the right shows the stem dying cells in purple. The mice are born with microcephaly, a characteristic feature of Seckel Syndrome (Image: Berta Terré, IRB Barcelona)
Scientific
A key role for CEP63 in brain development and fertility discovered
Jens Lüders leads the Microtubule Organization laboratory (Photo: Battista/Minocri, IRB Barcelona)
Scientific
A key component of cell division comes to light
irbbarcelona
Media mentions
The scientists who revealed the rules of cell trafficking receive the Nobel Prize
irbbarcelona
Scientific
IRB Barcelona participates in the resolution of the first structures achieved with the Alba synchrotron
Institutional
Cancer, ciliopathies, Alzheimer's and Parkinson's are some of the many diseases associated with defective cell transport